【摘 要】
:
By mimicking high density lipoprotein in the central nervous system(CNS),we constructed discoidal apolipoprotein E3-reconstituted high-density lipoprotein(A
【机 构】
:
Department of Pharmacology and Chemical Biology,Faculty of Basic Medicine,Shanghai Jiao Tong Univers
【出 处】
:
第三届国际纳米药物大会 ChinaNanomedicine 2018 The 3rd International Con
论文部分内容阅读
By mimicking high density lipoprotein in the central nervous system(CNS),we constructed discoidal apolipoprotein E3-reconstituted high-density lipoprotein(ApoE3-rHDL)as an efficient nanoplatform that could penetrate the blood-brain barrier(BBB)and accelerate Aβ clearance to serve as a novel nanomedicine for the therapy of AD.
其他文献
Radiotherapy is also one of the most important treatments of cancer.But it suffer from the serious side effects caused by the high dose X-ray irradiation.He
Extracellular vesicles(EVs)are nanosized membrane vesicles,released by many cell types,which are an ideal drugdelivery system for antitumor therapy.Exosomes
Proteins and nucleic acids are dynamically organized in cells to realize their physiological functions with spatial and temporal orderliness.This type of el
The accurate targeting and delivery of chemotherapy drugs into malignant tumor cells is essential for clinical treatment of cancer.Panels of overexpressed r
Organ-on-a-chip system,or microphysiological system(MPS),is a new type of biomedical research method that aims to recapitulate organ-level tissue structures
Self-assembly refers to a technology in which basic structural units spontaneously form ordered structures.Here we report that in recent years,our research
We firstly synthesize poly(lactic-co-glycolic acid)(PLGA)microspheres encapsulating HCuSNPs and paclitaxel followed by radioiodine-131 labelling(131I-HCuSNP
Atherosclerosis,a chronic inflammatory condition,is the most manifest contributor to myocardial infarction,ischemic stroke,and atherosclerotic aneurysm.Ther
Functional inorganic nanoparticles have shown great potentials in diagnosing major diseases such as cancer,atherosclerosis,etc.Through past years,we have be
Tumor angiogenesis is recognized as a major therapeutic target for anti-tumor therapy1.Many strategies have been used,including angiogenesis inhibitors,tumo