Transcriptional repressor--SIP1 as a critical regulator of skin fibrosis in pathological scars

• 作 者: Zhan-fengZhang;Dai-haiHu;Ji-hongshi;Feng-huaHan;Xiao-zhiBai;Wei-xiaCai;Hua-yuZhu;Chao-wuTang;
• 机 构: Burns Centre of PLA, Department of Burns and cutaneous surgery, Xijing Hospital,The Fourth Military
• 出 处: 中华医学会烧伤外科学分会2009年学术年会
• 发表日期: 2009年期

　　Keloids and hypertrophic scars are significant symptomatic clinical problems characterized by the excessive and abnormal deposition of collagen-based extracellular matrix (ECM) components.However,the molecular basis of keloid and hypertrophic scar formation has not been fully elucidated.Here,we demonstrate that down-regulation of transcriptional repressor-SIP 1 could be relevant to the keloid and hypertrophic sear formation.The results of this study show that SIP1 mRNA was significant decreased in pathological sear tissue and in human normal skin fibroblasts treated with TGF-β1.The mRNA levels of SIP1 has a remarkable inverse correlation with Colla2,or a direct correlation with MMP1.Overexpression of SIP1 could repress Colla2 expression and induce MMP1 expression in normal skin fibroblasts.