A novel 5'-uncoding region-1248 A>G variation of Mitofusion-2 gene is associated with hypert

来源 :第七届北京五洲心血管病研讨会 | 被引量 : 0次 | 上传用户：kdy520

【摘要】

：

【作者】

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Zuoguang Wan Shaojun Wen

【机构】

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Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Attached to Capita

【出处】

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第七届北京五洲心血管病研讨会

【发表日期】

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2013年12期

【关键词】

：

Hyperplasia suppressor gene mitofusion-2 single nucleotide polymorphism essentia

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　　Purpose Mitofusin2 gene (Mfn2,also named Hyperplasia suppressive gene,HSG) is very important in the origin and development of hypertension.However,the mechanism of Mfn2/HSG expression regulation was not uncovered.This study was designed to explore the association of a novel 5—uncoding region (UCR)-1248 A>G variation of HSG/Mfn2 gene and hypertension.Materials and Methods 472 healthy,normotensive (NT group),454 prehypertensive subjects (PH group) and 978 hypertensive patients (EH group) were screened for an association study between 5—UCR—1248 A >G of Mfn2/HSG and hypertension by polymerase chain reaction and DNA sequencing after venous blood was drawn and DNA was extracted.

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