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Purpose Although stem cell replacement therapy provide a prospective treatment for neural blindness,there are still fundamental unsolved problems,such as low-yield seed cell and potential tumorigenesis.This study was designed to reveal the critical genes or pathways control cell proliferation and tumorigenicity through the different genes among human embryonic retinal progenitor cells(hERPCs),human adult retina cells(hARCs)and human retinoblastoma cells(hRBCs)in order to acquire abundant seed cell with poor tumorigenicity.