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  5. Roflupram, a PDE4 Inhibitor, Recues Cognitive Dysfunction in APP/PS1 Transgenic Mice via cAMP/PKA/CR

Roflupram, a PDE4 Inhibitor, Recues Cognitive Dysfunction in APP/PS1 Transgenic Mice via cAMP/PKA/CR

来源 :2015全国老年痴呆与认知障碍相关疾病学术大会 | 被引量 : 0次 | 上传用户：guoaiet
【摘 要】
：
Background: So far, no PDE4 inhibitors in Alzheimers disease has been approved for application in the clinic due to severe side effects such as nausea and vomiting.Objective: In this study, we investi
【作 者】
：
Haibiao Guo Jiangping Xu 
【机 构】
：
Guangdong provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Sourth
【出 处】
：
2015全国老年痴呆与认知障碍相关疾病学术大会
【发表日期】
：
2015年9期
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Background: So far, no PDE4 inhibitors in Alzheimers disease has been approved for application in the clinic due to severe side effects such as nausea and vomiting.Objective: In this study, we investigated the effect of roflupram, a novel PDE4 inhibitor, on learning and memory ability as well as the underlying mechanism in APP/PS1 mouse model of Alzheimers disease.
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