The green tea polyphenol, epigailocatechin-3-gallate, possesses the antiviral activity against hepat

• 作 者: Z.J.Ma[1]Q.Li[2]S.B.Pu[2]J.B.Wang[2]B.Q.Jiang[2]X.H.Xiao[3]L.N.Zeng[2]Y.Lü[2]Y.L.Zhao[2]Y.W.Zhong[4]Y.Wang[3]L.F.Wang[3]D.K.Xiao[5]P.Zhang[2]
• 机 构: China Military Institute of Chinese Medicine, Beijing 100039, PR China
• 出 处: 2012转化医学与中药现代化高峰论坛
• 发表日期: 2012年期

　　Although several antiviral drugs and vaccines against hepatitis B virus (HBV) arc available,hepatitis caused by HBV remains a major public health problem worldwide that has not been resolved.New anti-HBV drugs are urgently needed.The present study was performed to investigate the anti-HBV activity of epigallocatechin-3-gallate (EGCG),a natural-origin compound,in HepG2 2.2.15 cells.The antiviral activity of EGCG was examined by detecting the levels of HBsAg and HBcAg in the supematant and extracellular HBV DNA.EGCG effectively suppressed the secretion of HBsAg and HBeAg from HepG2 2.2.15 cells in a dose-and time-dependent manner,and it showed stronger effects at 0.11-0.44 μmol/ml (50-200μtg/ml) than lamivudine (3TC) at 0.87 μmol/ml (200μg/ml).EGCG also suppressed the amount of extracellular HBV DNA.The data indicated that EGCG possessed anti-HBV activity and suggested the potential of EGCG as an effective anti-HBV agent with low toxicity.