【摘 要】
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目的： To evaluate the effects and mechanism of extrogenous Hyaluronate (HA) on promoting comeal wound healing 方法： Human corneal epithelial cell (HCEC)was in
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目的： To evaluate the effects and mechanism of extrogenous Hyaluronate (HA) on promoting comeal wound healing 方法： Human corneal epithelial cell (HCEC)was incubated with different concentrations of Hyaluronate (0.03％,0.3％) to evaluate its efficiency of promoting cell migration and its modulation of repair factor (FN and CD44).After treated with 0.1％ BAK and 90mmol/L NaCl-induced hyperosmolar conditions, the HCEC in ctrl, 0.03HA and 0.3HA group were detected the cell morphology, percentages of cell apoptosis and the expression of TNF-α and MMP-9 to analyze the protective roles of HA.Corneal epithelium defect rat models were established to test the therapeutic effects of 0.3％HA, then the wound healing rate was observed through silt lamp and inflammatory cytokines (IL-1β and MMP-9) and repair factor (FN and CD44) were detected by PCR.
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