Discovery of Novel Diarylpyrimidines as Potent HIV NNRTIs via A Structure-guided Core-refining Appro

• 作 者: Xiao Li Peng Zhan Xinyong Liu
• 机 构: Department of Medicinal Chemistry,Key laboratory of Chemical Biology(Ministry of Education),School o
• 出 处: 全国药物化学学术会议暨第四届中英药物化学学术会议
• 发表日期: 2013年期

　　Guided by crystal structures of HIV-1 RT/DAPY complex and molecular modeling studies,a series of novel DAPY derivatives were rationally designed,synthesized and evaluated for their anti-HIV activities.