PDCD5影响iNKT细胞的终末分化

来源 :中国免疫学会第十届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：kueixing

【摘要】

：

背景：iNKT (invariant natural killer T)细胞为一群表达Vα14-Jα18 TCR的T细胞,它具有CD1d限制性.iNKT细胞从胸腺中的双阳细胞(DP)发育而来,经历iNKT特异的阳性选择后需要依次经过四个阶段(stage 0,stage 1,stage 2,stage 3)发育至成熟.

【作者】

：

王渴陈英玉葛青

【机构】

：

北京大学医学部免疫学系北京大学医学部免疫学系;北京大学人类疾病基因研究中心

【出处】

：

中国免疫学会第十届全国免疫学学术大会

【发表日期】

：

2015年10期

【关键词】

：

PDCD5 iNKT细胞终末分化

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

细胞自噬抑制小鼠肿瘤相关巨噬细胞分化的机制研究

目的：细胞自噬对于一些细胞的分化起到重要作用，例如红细胞，淋巴细胞，脂肪细胞，以及原代单核细胞等。但自噬在M1型巨噬细胞向M2型肿瘤相关巨噬细胞转化的过程中是否发挥作用还不得而知。本研究着重于研究自噬在肿瘤微环境中发挥的作用，探索其在驯化肿瘤相关巨噬细胞表型转化中的角色，以及对肿瘤转移浸润的影响。

会议

肿瘤微环境M2型肿瘤相关巨噬细胞自噬ROS

Acute Liver Failure Attenuative Effects of Tamoxifen through Anti-Oxidative Stress Action

Background: Acute liver failure (ALF) is a severe hepatic syndrome in clinic, which signifies by acute hepatic injury, and eventual death.Up to now, aside from supportive therapy and surgical operatio

会议

acute liver failureoxidative stressTamoxifen

Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-

Cryptococcus neoformans (C.neoformans) is an opportunistic fungal pathogen which causes Cryptococccosis in immunocompromised patients as well as immunocompetent individuals.Host cell surface receptors

会议

Cryptococcus neoformansInflammasomeNLRP3Caspase-8Caspase-1

TMEM208 contains functional WH2 domain and prolyl hydroxylation motif

We previously reported a new cell stress regulated membrane protein, TMEM 208 (PLoS ONE 2013, 8(5): e64228).TMEM208 locates in endoplasmic reticulum, and regulates cell autophagy and ER stress respons

会议

TMEM208WH2prolyl hydroxylationautophagy

Roles of autophagy and pattern recognition receptors in regulating the innate antiviral responses in

Background : Various viruses may infect adipose tissues.Some viral infections may cause chronic inflammatory responses.Innate antiviral responses in the adipose cells is important issues in the field.

会议

adipocytesinnate antiviral responsespattern recognition receptorsautophagy

Crystal Structure of Zebrafish ASC and Implication in Inflammasome Activation

Purpose: Abnormal activation of inflammasome is associated with human various diseases, so it is of great significance to in-depth understand the mechanism of inflammasome regulation.

会议

inflammasomeASCzebrafish

F-box Only Protein Fbxo21 Is Required for Lys29-1inkage of ASK1 and Cell Death during Innate Antivir

Innate immune system is the first defense that protects the host from infection by pathogenic organisms.Recognition of viral components by pattern-recognition receptors(PRRs) and initiation of program

会议

Innate anti-viral immunitymacrophageFBXO21SKP1-CUL1-F-box protein complexASK

Integrin CD11b attenuates DSS-induced colitis by promoting TLR-triggered IL-10 expression in macroph

Integrins are critical for migration and function of leukocytes in inflammation and autoimmune diseases.Integrin CD11b on DCs inhibits full T-cell activation and facilitates the development of periphe

会议

CD11bTLRIL-10colitis

固有淋巴样2型细胞在组织、器官中定向聚集的动态分析和机制研究

目的：固有淋巴样2型细胞(innate lymphoid cells type 2,ILC2)是一类表达IL-7Rα、IL-17BR和T1/ST2的非T非B细胞。活化的ILC2可以产生大量Th2型细胞因子IL-5、IL-13和少量的IL-4,进而促进Th2型免疫应答。课题组研究发现IL-25和IL-33可诱导ILC2向肺内聚集,然而,ILC2向肺内聚集的机制尚不明确。本研究旨在比较IL-25和IL

会议

固有淋巴样2型细胞IL-25IL-33哮喘

The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral

Aim: Viral fulminant hepatitis (FH) is a severe disease with high mortality resulting from excessive inflammation in the infected liver.Clinical interventions have been inefficient due to the lack of

会议

IL-1βNLRP3ROSMHV-3p47phox

PDCD5影响iNKT细胞的终末分化

其他学术论文