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Background: Axillary osmidrosis can be distressing both at work and psychosocially.The malodour manifested in conjunction with hyperhidrosis sometimes makes the affected individual embarrassed and socially withdrawed.Various conservative measures and surgical procedures have been devised for the conditions.Almost all the medical therapies are neither effective nor long-lasting.The surgical techniques carried certain significant postoperative morbidities and complications.Objective:There are still relatively few to treat the bromidrosis in a less invasive way with similar cure rate.We evaluated and shared some experience on the efficacy, downtime and complication of dermal ablation using the mechanism of 1444nm Nd-YAG laser lipolysis system.Since it manages to provide the shortest pulse width as 100us which is 10 times shorter than other similar laser systems, it conducts a selective photodermolysis for apocrine ablation much safer by confining the heat diffusion to prevent scald burns or damages to the surrounding tissue.Methods: Fifteen patients underwent the axillary photodermolytic curretage procedure after the infiltration of tumescent anaesthetic solution from August 2010 to January 2011.Eight of them had their residual fluid aspirated postoperatively in order to reduce the subcutaneous cell debris in terms of cytokines concentration concerning the shorter recovery time.Results: Twelve of the 15 patients (80%) had good to fair results; only three (20%) showed poor results requiring another touch-up treatment.None had shown focal ulceration, infection, scald burn or skin necrosis.Only one (6.7%) suffered from focal ecchymosis which resolved in a week.All of them returned to their work on the following day.The patient with postoperative, additional suction showed less wound swelling.Conclusion:The current aesthetic trends to less invasive, more safe and effective medical means, we address the study applying the highly selective laser photothermolysis as the treatment of choice for the management of osmidrosis.The procedure has the advantages of extraordinarily low complications with relatively high successful rate, no admission required, minimal to no scarring, prompt recovery time.The additional aspiration of the residual subcutaneous fluid seems not necessary since the consequent effects may not make any difference.