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The particle deposition patterns are numerically simulated within three three-dimensional models of the humanairways geometry, which is based on the Weibel A model. It’s the first comprehensive attempt to compute theeffects of deposition mechanisms on particle deposition in different airway models, with the mouth inlet flow ratefrom 3 to 60 l/min. Meanwhile, particles in the size range of 0.001-10μm are conducted. Three particle depositionmechanisms, gravitational sedimentation, inertial impaction and brownian diffusion, are considered in this work.The particle transport was traced by the Lagrangian particle tracking method implemented in Fluent DiscretePhase Model (DPM). The results will show that different particle deposition patterns occurs in different airwaymodels due to different mechanisms. Particles smaller than 0.1μm can be only deposited due to Brownian force atthe deeper lung region, I.e., G16-G18, where airflow rate is very low. Particles in the size range of 0.1-2 μm canbe mainly deposited in the medium bifurcations, I.e., G9-G11, due to the gravitational sedimentation. Largerparticles can be deposited in the proximal bifurcations, I.e., G3-G5, due to the inertial impaction. The results willindicate that the use of the three airway models can be fully representative, and the Lagrangian method is usefulfor studying the three particle deposition mechanisms in different airway models.