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Kelch-like ECH-associated protein-1 (Keap 1) is a pluripotent protein,which plays an important role in stress responses,especially in oxidative stress.Firstly,Keapl is an important adaptor compo-nent in the Cullin 3 (Cul3)-based E3 ligase,which is the primary regulator of NF-E2-related factor-2 (Nrf2) through mediating the ubiquitination of Nrf2.1,2 Nrf2 is the master regulator of the cellular defense mechanism by eliciting an adaptive defense system under oxidative stress.