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pH-responsive drug delivery systems are promising in their applicability to many areas,especially the anti-cancer therapy.Coordination complexes have the capability of storing and releasing drugs through the formation and cleavage of coordination bonds, respectively, in response to pH variations.This presentation outlines recent advances in coordination bonding based pH-responsive systems in both host carrier systems and coordination polymer systems.Various strategies have been developed for drug molecules with strong coordination binding sites, weak coordination binding sites and no coordination binding sites.The binding strengths of pH-responsive systems, using different types of metal sources, are discussed in this article.The construction of various pH-responsive systems using different categories of carriers, including mesoporous silica nanoparticles, mesoporous hybrid monoliths,mesoporous metal oxides and coordination polymer nanoparficles, has also been achieved.This presentation also provides a perspective on utilizing this system in in vitro cell assays and in vivo tumor assays as well as further possibilities for clinical applications.