“HSF1-miR-449b-DNA损伤应答基因XPC”通路促进膀胱尿路上皮癌发生、发展的作用及机制的研究

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户：talygs

【摘要】

：

DNA损伤应答过程的异常可导致肿瘤基因组的高度不稳定，与肿瘤的发生、发展密切相关.XPC作为DNA损伤应答过程的早期信号启动分子，我们前期工作首次发现XPC通过调控P53通路影响细胞周期、凋亡和DNA修复等系列重要生命活动，同时首次证实了膀胱癌的发生、发展与XPC表达缺陷密切相关.

【作者】

：

黄亚琴王志陈志文杨劲

【机构】

：

第三军医大学基础部细胞生物学教研室,重庆市400038 第三军医大学附属西南医院全军泌尿外科研究所

【出处】

：

中国细胞生物学学会2015年全国学术大会

【发表日期】

：

2015年4期

【关键词】

：

膀胱尿路上皮癌 HSF1 miR-449b XPC

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“HSF1-miR-449b-DNA损伤应答基因XPC”通路促进膀胱尿路上皮癌发生、发展的作用及机制的研究

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