【摘 要】
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Recently, mesoporous silica nanoparticles (MSN) have attracted much attention because they can serve as novel nanocarriers for on-demand drug release.Howeve
【机 构】
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兰州大学化学化工学院,功能有机分子化学国家重点实验室,兰州730000
【出 处】
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第九届全国高聚物分子与结构表征学术讨论会
论文部分内容阅读
Recently, mesoporous silica nanoparticles (MSN) have attracted much attention because they can serve as novel nanocarriers for on-demand drug release.However, many of the existing capping MSN have disadvantages.Therefore, the search for effective capping agents combining multifunction simultaneously, such as end-capped properties, bioactive targeting ability, still remains a big challenge and has been a research hotspot.Herein, multifunctional mesoporous silica nanoparticles were facilely prepared by LbL assembly method, with biocompatible PAMAM dendrimers and chondroitin sulphate, possessing auto-fluorescent property and targeting ability, enabling to encapsulating two kinds of drug with different loading mechanism and allowing their release upon exposure to cellular lysosomal pH and enzyme.
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