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目的:探讨慢性乙型重型肝炎患者生存因素与中医辨证分型、中西医结合治疗的相关性。方法:回顾性收集2006年1月-2009年12月间在首都医科大学附属北京佑安医院住院的365例慢性乙型重型肝炎患者临床资料,采用多因素COX比例风险回归方法进行分析。结果:本组慢性乙型重型肝炎患者中位生存期为(3±1)个月,平均生存时间为(26±2)个月。虚证组、实证组与虚实夹杂证组生存曲线比较,Log Rank检验、Breslow检验均显示差异无统计学意义,而虚证组、实证组的生存率各为27.47%、49.33%,差异有统计学意义(P<0.05)。中西组患者的生存率为38.85%,明显高于西医组的生存率25.42%(P<0.05)。结论:慢性乙型重型肝炎生存预后与中医辨证分类和中西医结合治疗密切相关。
Objective: To investigate the relationship between the survival factors of chronic severe hepatitis B and syndrome differentiation of traditional Chinese medicine (TCM) and the combination of traditional Chinese and western medicine. Methods: The clinical data of 365 patients with chronic severe hepatitis B hospitalized in Beijing You’an Hospital Affiliated to Capital Medical University from January 2006 to December 2009 were retrospectively collected and analyzed by multivariate COX proportional hazards regression analysis. Results: The median survival time of patients with chronic severe hepatitis B was (3 ± 1) months and the average survival time was (26 ± 2) months. There were no significant differences in survival curves between the syndromes of the deficiency syndrome and the syndromes of the syndromes of the actual group and the syndromes of the syndromes of the actual situation and the syndromes. Log Rank test and Breslow test showed that the difference was not statistically significant, while the survival rates of the syndromes and the syndromes were 27.47% and 49.33% respectively. Significance (P <0.05). The survival rate of Chinese and Western patients was 38.85%, which was significantly higher than that of Western medicine group (25.42%, P <0.05). Conclusion: The survival prognosis of chronic severe hepatitis B is closely related to TCM syndrome differentiation and Integrative Chinese and Western medicine treatment.