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Objectives: To conduct a preliminary evaluation of the use of two-dimensional(2D)enhanced multiecho T2*-weighted angiography(ESWAN)sequence for detection and quantification of siderotic nodules(SNs)in patients with liver disease.Materials and Methods: Seventy-four patients with liver cirrhosis SNs confirmed by pathology were imaged using conventional T1-weighted imaging(T1WI),T2-weighted imaging(T2WI),T2*-weighted imaging(T2*WI),and 2D ESWAN.The signal intensity ratio(SIR)and the lesion-to-liver contrast-to-noise ratio(CNR)were calculated.The quality of SNs identification of the ESWAN images was evaluated.