【摘 要】
：
With current treatment protocols more than 85% of adults with acute lymphoblastic leukemia (ALL) achieve complete remission (CR), however, approximately hal
【机 构】
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Department of Hematology and Bone Marrow Transplantation Silesian Medical University in Katowice Pol
【出 处】
：
BIT Life Sciences' 1st Annual World Cancer Congess-2008(
论文部分内容阅读
With current treatment protocols more than 85% of adults with acute lymphoblastic leukemia (ALL) achieve complete remission (CR), however, approximately halfofCR patients subsequently relapse, which is unequivocally associated with poor prognosis.The major task is to identify high-risk patients who require intensified post-remission therapy as well as to apply new drugs targeting molecular and phenotypic features characterizing particular subtypes of the disease.Conventional criteria for high-risk ALL include initial tumor burden (WBC >30 x109/L for B-lineage ALL), higher age, adverse immunophenotype (pro-B, early-T, mature-T), late CR achievement, and adverse karyotype (t(9;22), t(4;11)).
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