【摘 要】
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Photosensitized DNA damage has been widely investigated since DNA is the primary intracellular target of anticancer drugs for photodynamic therapy (PDT),a minimally invasive treatment for malignant tu
【机 构】
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Laboratory of Organic NanoPhotonics and Key Laboratory of Functional Crystals and Laser Technology,T
【出 处】
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中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议
论文部分内容阅读
Photosensitized DNA damage has been widely investigated since DNA is the primary intracellular target of anticancer drugs for photodynamic therapy (PDT),a minimally invasive treatment for malignant tumors.1 Many photosensitizers have been confirmed to possess DNA photocleavage activity but suffer the disadvantage of relatively weak absorbance in the phototherapeutic window of 700-900 nm,limiting their further application in PDT.2 Herein,a novel carbazole derivative,BMEPC,was designed and synthesized as DNA photocleaver.
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