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  5. Tolerance of DNA Damage by Translesion DNA Synthesis

Tolerance of DNA Damage by Translesion DNA Synthesis

来源 :2009第四届国际基因组学大会) | 被引量 : 0次 | 上传用户：holy1987
【摘 要】
：
Cells that carry unrepaired DNA damage are subject to arrested DNA replication,a lethal event unless the arrest is relieved and normal DNA replication continues
【作 者】
：
Errol C.Friedberg Nicole Kosarek-Stancel Lisa D.McDaniel Su 
【机 构】
：
LaboratoryofMolecularPathology,DepartmentofPathology,UniversityofTexasSouthwesternMedicalCenteratDal
【出 处】
：
2009第四届国际基因组学大会)
【发表日期】
：
2009年11期
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论文部分内容阅读
Cells that carry unrepaired DNA damage are subject to arrested DNA replication,a lethal event unless the arrest is relieved and normal DNA replication continues.Prokaryotic and eukaryotic cells have evolved multiple mechanisms for relieving arrested DNA replication without removing lesions from DNA,a biological response called DNA damage tolerance.
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