论文部分内容阅读
Study Objectives: The aim of the study was to investigate the cognitive function of patients with primary restless legs syndrome/Willis-Ekbom disease(RLS/WED)in a Chinese population.Methods: A total of 40 patients with RLS/WED who were drug na(i)ve and 40 controls,matched by age,sex,and educational level,were evaluated by cognitive function assessments,including the Chinese version of the Mini-Mental State Examination(MMSE-C),clock drawing test(CDT),Auditory Verbal Learning Test(AVLT),Rey-Osterrieth Complex Figure Test(CFT),and Stroop Color Word Test(SCWT).Results: Patients with RLS/WED showed worse performance on the SCWT(Stroop Card C time: 102.36 ± 17.12 versus 87.08 ± 7.73 seconds,P =.033; Interference Index: 3.39 ± 0.38 versus 2.90 ± 0.15,P <.0001),CFT(24.05 ± 9.28 versus 33.74 ± 1.59,P =.008),and CDT than controls(16-score method: 10.13 ± 3.94 versus 13.98 ± 1.79,P =.0002)after adjusting for Hamilton Anxiety Scale score,Hamilton Depression Scale score,Epworth Sleepiness Scale score,and Pittsburgh Sleep Quality Index total score to eliminate the confounders of concomitant sleep disturbances,anxiety,and depression.Conclusions: Our study suggested that cognitive functions involving executive and visuospatial domains might be disturbed in Chinese patients with primary RLS/WED.