Predicting cancer-relevant proteins using an improved molecular similarity ensemble approach

来源 :第八届国际分子模拟与信息技术应用学术会议 | 被引量 : 0次 | 上传用户：sprinia

【摘要】

：

　　In this study,we proposed an improved algorithm for identifying proteins relevant to cancer.The algorithm was named two-layer molecular similarity ensemble

【作者】

：

BinZhou;QiSun;De-XinKong;

【机构】

：

State Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,Chin

【出处】

：

第八届国际分子模拟与信息技术应用学术会议

【发表日期】

：

2016年期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　In this study,we proposed an improved algorithm for identifying proteins relevant to cancer.The algorithm was named two-layer molecular similarity ensemble approach(TL-SEA).We applied TL-SEA to analyzing the correlation between anticancer compounds(against cell lines K562,MCF7 and A549)and active compounds against separate target proteins listed in BindingDB.Several associations between cancer types and related proteins were revealed using this chemoinformatics approach.An analysis of the literature showed that 26 of 35 predicted proteins were correlated with cancer cell proliferation,apoptosis or differentiation.Additionally,interactions between proteins in BindingDB and anticancer chemicals were also predicted.We discuss the roles of the most important predicted proteins in cancer biology and conclude that TL-SEA could be a useful tool for inferring novel proteins involved in cancer and revealing underlying molecular mechanisms.

其他文献

不同寒热药性海洋中药在海洋生物系统发育树的分布规律及其关联关系分析

目的:海洋中药是我国中药资源宝库的重要组成部分,海洋生物资源的开发为海洋中药的发展奠定了基础,如何快速客观评价海洋中药新资源的药性已成为制约海洋中药发展和临床应用

会议

Synthesis,Molecular Modeling,and Biological Evaluation of Novel 1,3-Diphenyl-2-propen-1-one Based Py

　　A novel series of 1,3-diphenyl-2-propen-1-one(chalcone)derivatives was synthesized by a simple,ecofriendly,and efficient Claisen-Schmidt condensation reacti

会议

Synthesis and biological evaluation of novel aryl-2H-pyrazole derivatives as potent non-purine xanth

　　A series of aryl-2H-pyrazole derivatives were synthesized and evaluated for inhibitory activity against xanthine oxidase in vitro as potent xanthine oxidase

会议

Synthesis,biological evaluation and molecular modeling of 1H-benzo[d]imidazole derivatives as novel

　　A series of novel compounds(8a-21b)were designed and synthesized based on lH-benzo[d]imidazole.Their biological activities were evaluated as potential tubul

会议

Synthesis and antibacterial evaluation of novel Schiff's base derivatives of nitroimidazole nuc

　　Series of novel Schiff's base derivatives have been synthesized by combining 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl 4-formylbenzoate 5,6 with aromatic/h

会议

Synthesis and Biological Evaluation of 1-Methyl-1H-indole-Pyrazoline Hybrids as Potential Tubulin Po

　　A series of 1-methyl-1H-indole-pyrazoline hybrids were designed,synthesized,and biologically evaluated as potential tubulin polymerization inhibitors.Among

会议

Synthesis and biological evaluation of novel indole derivatives containing sulfonamide scaffold as p

　　Microtubule-targeted drugs play a critical role in various types of cancer therapy worldwide.In our study,a series of novel indole derivatives containing su

会议

Navigating into the chemical space between MGCD0103 and SAHA:novel histone deacetylase inhibitors as

　　Histone deacetylase inhibitors(HDIs)are an increasingly important class of cancer-targeting agent.Two kinds of small molecule histone deacetylase inhibitors

会议

Synthesis,biological evaluation and molecular docking studies of novel l-(4,5-dihydro-lH-pyrazol-1-y

　　A series of novel compounds(6a-6v)containing l-methylindol and 31-(4,5-dihydro-lH-pyraxol-1-yl)ethanone skeleton were designed,synthesized and biologically

会议

Inflammatory pathway network-based drug repositioning and molecular phenomics

会议

Predicting cancer-relevant proteins using an improved molecular similarity ensemble approach

其他学术论文