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Chronic kidney disease (CKD) is increasingly recognized as a major public health issue.Drug targeting delivery to the kidney is an attractive method to increase the drug efficacy,as this approach will generate higher renal drug concentration.Peptides extensively used as vehicles of radioactivity for targeted imaging and radiolabeled peptides also caused high and persistent localization of radioactivity in the kidney In addition,the renal uptake owes to the peptides carrier rather than the radiometabolite.