【摘 要】
：
Nucleosides are essential building blocks of RNA and other related biomolecules.Normal metabolism of RNA generates free nucleosides, which can be reused to
【机 构】
：
State Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering
【出 处】
：
第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
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Nucleosides are essential building blocks of RNA and other related biomolecules.Normal metabolism of RNA generates free nucleosides, which can be reused to build new RNA.However, abnormal cell status such as cancer cell generation will produce nucleosides with different kinds of medication.As modified nucleoside can not be used to assembly RNA, they are released to urine.Thus, urinary modified nucleosides can be used as potential biomarkers for early detection of cancers.As modified nucleosides are present in very low concentration at early stage of cancer development, their specific and effective enrichment is a key and challenging step for early detection of cancers.
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