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OBJECTIVE: This study aimed to establish HUVEC apoptosis model, using Western blot to detect changes of apoptosis-related protein Bcl-2, Bax and caspase-3 before and after Ang Ⅱ caused HUVEC apoptosis.The content of intracellular ROS was measured after Ang U reaction, and the impact of blueberry anthocyanin in above circumstances was observed to investigate the protective effect of blueberry anthocyanin in HUVEC.