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目的 Low expression of linker for activation of T cells (LAT) is observed in cases of asthma.LAT and its downstream regulator PLC-γ1 play important roles in the T cell antigen receptor (TCR) signaling pathway,and their interaction is associated with CD4+ cell polarization.Here,we investigated whether LAT can alleviate the imbalance among CD4+ cell subgroups and the possible mechanism of this effect in vivo.方法 An OVA-induced allergic asthma mouse model was established and LAT plasmid was delivered either before or after OVA airway challenge.