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Objective:To compare the efficacy on muscle recruitment and coordination of constraint therapy,constraint therapy plus electrical stimulation,and occupational therapy,to treat the hand dysfunction.Method: Sixty-eight children with hemiplegic cerebral palsy were randomly allocated to constraint therapy,constraint therapy plus electrical stimulation,and occupational therapy group.Three groups received two weeks of treatment.All participants were measured at baseline and two weeks,three and six months after treatment using measures of surface electromyography.Results: When grasping maximally used by involved hand,root mean square of both hands,integrated electromyography and co-contraction ratio of involved hand changed significantly at each follow-up session for all children,as well as reducing in integrated electromyography of noninvolved hand after six months of treatment (P <0.05).Constraint-induced movement therapy plus electrical stimulation group showed greater rate of improvement in integrated electromyography of involved wrist extensors,and co-contraction ratio than other two groups at three and six months,as well as improving in root mean square of involved wrist extensors than occupational therapy group (P <0.05).When grasping maximally used by noninvolved hand,all children changed significantly in root mean square of both involved hand and wrist extensors of noninvolved hand from baseline to each follow-up session,as well as reducing in integrated electromyography of wrist extensors of involved hand after six months of treatment for constraint-induced movement therapy plus electrical stimulation group (P <0.05).Conclusion: Constraint therapy plus electrical stimulation is likely to be best in strengthening recruitment and coordination of involved arm,and isolated movement control ability of bimanual hand in children with hemiplegic cerebral palsy.