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Objective The inward rectifier potassium channel (Kir) is expressed in various types of excitable cells.It conducts strong inner current under hyperpolarization and weak outer current under depolarization.Previous study carried out in our lab indicated that Kir current could be inhibited by Zn2+ at specific pH acidity.The present study proposes a model to describe the Kir current and explore the underlying mechanism of Zn2+ inhibitory effect.Methods The model was simulated with NEURON software based on HH equation and state-transfer diagram.Statistical analysis of the models parameters was performed with SPSS software.Results (1) The Kir models parameters for different trials without Zn2+ were identical.(2) With the alteration of Zn2+ concentration, parameter standing for Zn2+ binding rate constant and H+ binding rate kept unchanged.(3) With the increase of Zn2+ concentration, Zn2+ unbinding rate increased and the H+ unbinding rate decreased.Conclusions (1) This model is suitable for describing Kir both with and without Zn2+.(2) Zn2+ can inhibit Kir by binding to specific sites and causing states transfer.