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“As we move forward, I predict newer search engines built around ETD fragmentation patterns, rather than adapted from a CAD point of view, will further improve ETD performance." ETcaD: H atom loss or gain c-type ions can lose a H atom to become c·-type, while z-type fragments gain the H atom to generate z-type ions.“However, the database search algorithms we used OMSSA) had difficulty with the 1-Da ambiguity of many newly generated fragment ions. I predict that with further development this search algorithm issue will likely be resolved, and we can expect the ETcaD method to offer excellent performance across a very broad precursor m/z range."