Prognostic Analysis of Prognostic Nutritional Index (PNI) in Patients with Esophageal Squamous Cell

• 作 者: Ji-FengFeng;Jin-ShiLiu;QiangZhao;Qi-XunChen;Xin-MingZhou;
• 机 构: Department of Thoracic Surgery,Zhejiang Cancer Hospital, Hangzhou 310022, China
• 出 处: 2014华东胸部肿瘤论坛暨第七届浙江省胸部肿瘤论坛
• 发表日期: 2014年期

　　Background:Prognostic nutritional index (PNI) relates to prognosis in many cancers,however,its role in esophageal cancer (EC) is still controversial.The aim of this study was to determine the prognostic value of PNI and propose the optimal cut-off points for PNI in predicting cancer-specific survival (CSS) in esophageal squamous cell carcinoma (ESCC).Methods:This retrospective study included 375 patients who underwent esophagectomy for ESCC.The PNI was calculated as 10×serum albumin (g/dl)+0.005 × total lymphocyte count (per mm3).Results:PNI was associated with tumor length(P=0.007),T grade (P=0.001) and N staging (P<0.001).The 5-year CSS in patients with PNI <42,42-52,and >52 were 11.0% ,39.1% and 55.2%,respectively(P<0.001).Multivariate analysis showed that PNI was a significant predictor of CSS (PNI 42-52 versus PNI>52, P=0.019; PNI<42 versus PNI>52, P<0.001),Conclusion:PNI is a predictive factor for long-term survival in ESCC.The survival rate of ESCC can be discriminated between three groups:PNI <42,42-52,and >52.