Lactic acid and female vaginal secretion inhibit seminal amyloid fibril formation in vitro

来源 :广东省药理学会第七届2015学术交流大会 | 被引量 : 0次 | 上传用户：kona

【摘要】

：

【作者】

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Suiyi Tan Tianrong Xun Yali Song Jinqing Li Lin Li Shuwen Liu

【机构】

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School of Pharmaceutical Sciences, Southern Medical University, Guangzhou,Guangdong, China

【出处】

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广东省药理学会第七届2015学术交流大会

【发表日期】

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2015年7期

【关键词】

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HIV-1 sexual transmission SEVI vaginal secretion lactic acid

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　　Background: Semen is an important vehicle for HIV-1 sexual transmission.Semen harbors various amyloid fibrils,termed semen-derived enhancer of viral infection (SEVI),SEVI could greatly enhance HIV-1 infectivity and it is a potential target for microbicide design.Several reports have showed the effects of semen on SEVI fibril formation.However,little study investigated the role of lactic acid,the main component of the female vaginal secretion,and female vaginal secretion in SEVI fibril formation.

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Lactic acid and female vaginal secretion inhibit seminal amyloid fibril formation in vitro

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