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  5. S897 phosphorylation of EphA2 is indispensable for EphA2-dependent nasopharyngeal carcinoma cell inv

S897 phosphorylation of EphA2 is indispensable for EphA2-dependent nasopharyngeal carcinoma cell inv

来源 :2019中国肿瘤学大会 | 被引量 : 0次 | 上传用户：liongliong555
【摘 要】
：
Objective The phosphorylation of EphA2 at serine 897(pS897-EphA2)plays a key role in the ligand-independent functions of EphA2.The ligand-independent promotion of cancer cell migration and invasion by
【作 者】
：
Zhiqiang Xiao 
【机 构】
：
Research Center of Carcinogenesis and Targeted Therapy,Xiangya Hospital,Central South University,Cha
【出 处】
：
2019中国肿瘤学大会
【发表日期】
：
2019年7期
【关键词】
：
PS897-EphA2 Nasopharyngeal carcinoma Metastasis Cancer stemness Signaling pathwa 
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　　Objective The phosphorylation of EphA2 at serine 897(pS897-EphA2)plays a key role in the ligand-independent functions of EphA2.The ligand-independent promotion of cancer cell migration and invasion by EphA2 requires pS897-EphA2,which is induced by AKT or RSK(ribosomal S6 kinase).
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