MiR344b-1-3p targets TLR2 and negatively regulates TLR2 signaling pathway

• 作 者: 徐虹 吴玉婷 李理 袁伟锋 张德明 严启韬 郭振辉 黄文杰
• 机 构: 广州军区广州总医院呼吸科 510000
• 出 处: 2016中南六省呼吸病学论坛、岭南呼吸论坛暨广东省医学会第十九次呼吸病学/第十三次结核病学学术会议
• 发表日期: 2016年8期
• 关键词: COPD miR344b-1-3p TLR2 invasive pulmonary aspergillus

　　This study aims to identify the miRNA involving in the regulation of TLR2 expression and signaling of COPD AMs in vivo and in vitro.By smoke inhalations,COPD rats were successfully prepared.Among 11 up-regulated miRNAs in AMs from COPD rats,miR-344b-1-3p was predicted to be a novel miRNA targeting TLR2 and confirmed high-level expression in AMs from COPD rats,as well as was validated to target TLR2 3UTR.