NIR Fluorescent Copper Sensor for Ratiometric Imaging in Mice

来源 :第十一届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：huohuonan

【摘要】

：

Most copper in living organisms functions as essential co-factors of metabolic enzymes that participate in a variety of physiological processes,[1] which are dependent on copper homeostasis.Therefore

【作者】

：

Hongxia Xu Changli Zhang Shuren Zhang Zijian Guo Weijiang He

【机构】

：

State Key Laboratory of Coordination Chemistry,School of Chemistry and Chemical Engineering,Nanjing

【出处】

：

第十一届全国化学生物学学术会议

【发表日期】

：

2019年3期

【关键词】

：

copper NIR ratiometric imaging mice fluorescence

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Most copper in living organisms functions as essential co-factors of metabolic enzymes that participate in a variety of physiological processes,[1] which are dependent on copper homeostasis.Therefore tracking copper homeostasis in situ via fluorescence imaging is attracting much interests of scientists in this field.

其他文献

偶氮还原酶低氧荧光探针前药的合成研究

近年来，作为对低氧敏感，能靶向识别肿瘤和癌细胞的偶氮还原酶探针已经被广泛报道[1-3]。偶氮还原酶全称为细胞色素P450还原酶，广泛存在于生物体内，并且在癌细胞中过度表达，并且低氧是实体瘤的一个重要特征，因此可以通过检测偶氮还原酶来间接的诊断检测细胞的病变状况。

会议

荧光探针低氧偶氮还原酶前药

The Detection of Phosgene with the Near Infrared Fluorescent Probe

Phosgene is one of the most toxic substances and this substance has gained infamy for it was a chemical weapon agent during the World War Ⅰ.1 Phosgene has led to nearly 80% of the poison gas deaths an

会议

PhosgeneNIR Probe

具有内在标准的两亲性石墨化含银纳米粒子的合成:一种有效的策略,用于在普通液体中进行可靠的SERS定量分析

采用叠氮化物对石墨化含银纳米粒子(AGSN)进行两亲官能化处理，为液体中SERS的定量分析提供了可靠的依据.AGSN由贵金属合金AgCu芯和多层石墨壳组成.AGSN集成了核心强大的SERS性能，以及惰性石墨外壳与生俱来的内部标准拉曼信号和化学稳定性.

会议

双亲性纳米颗粒AGSNs石墨化贵金属SERS技术

一种单一有机小分子作为三模态探针的设计、合成与性质研究

医学成像是医学诊断的最重要基础。发展高空间分辨率、高探测深度、高特异性多模态分子探针是目前设研究的主要目标[1]。我们设计了一种1,4,7,10-四氮杂环十二烷-1,4,7-三乙酸(DO3A)的2-氨基-6 甲基吡啶衍生物与镧系元素配合形成的分子探针,通过对合成路线的优化,得到该分子并进行了基础表征、X 射线晶体结构测试,核磁共振测试和光学测试,证明钆(Gd)、铽(Tb)和镱(Yb)三种元素的2-

会议

分子探针设计与合成镧系元素核磁共振成像光学成像酶响应

A gold-selenium-bonded nanoprobe for real-time in situ imaging of the upstream and downstream relati

Tumour progression is closely related to the abnormal activation of signalling pathways involving uPA-mediated MMP-9 activation.The study of protein expression levels and their relationships will prom

会议

uPAMMP-9Au-Se nanoproberegulatory relationships

A MOF-based nanozyme fluorecent sensor for efficiently detecting tyrosinase activity

Tyrosinase is used as a biomarker for melanoma cancer cells because it relates to the formation of melanin by mediating the oxidation of tyrosine to quinones.[1] Here,Fe-MIL-88B-NH2 was chosen as pero

会议

Fe-MIL-88B-NH2fluorescence quenchingtyrosinase

Construction of an Alkaline Phosphatase-Specific Two-photon Probe and Its Imaging Application in Liv

Monitoring the activity of ALP in serum can help diagnose a variety of diseases including bone and liver diseases.[1] There has been growing interest in developing new chemical tools for monitoring AL

会议

Platinum complexNMRG-quardruplexdynamic binding

Design,Construction,Characterization and Application of Chitosan Derivatives with pH Response and Su

How to realize high sensitivity analysis of the thiol-containing peptides from cell using Mass spectrometry is still a challenge,as thiol-free peptides is too high compared with thiol-containing pepti

会议

Chitosan DerivativespH responseEnrichmentSulfhydryl Adsorption/desorptionMas

共价键标记耐药病菌荧光探针研究

b-内酰胺类抗生素是当前临床应用最为广泛的一类治疗细菌感染的药物。然而，随着这类抗生素在临床中的大量使用，耐药病菌逐渐出现并在全球呈现迅速蔓延之势，这对人类的健康造成了严重的威胁。病菌耐药性产生的一个主要原因是其产生了一种能够快速水解、破坏b-内酰胺类抗生素的酶，即b-内酰胺酶。

会议

抗生素耐药β-内酰胺酶荧光探针共价键标记

一种荧光增强型Hg2+探针

荧光探针具有灵敏度高、选择性好、实时监测等优点,是Hg2+检测的理想选择[1,2].在这项工作中,我们提出了一种荧光增强型Hg2+探针PEM.通过荧光发射光谱来评估探针对不同的常见金属离子的选择性.向PEM 的乙醇溶液(10μM)中加入Hg2+后,荧光强度增大了约25 倍(图a,b).

会议

荧光探针Hg2+

NIR Fluorescent Copper Sensor for Ratiometric Imaging in Mice

其他学术论文