【摘 要】
：
Growth and division are inherently disparate processes that are intimately coupled through a delicate network of intracellular signaling programs and extrac
【机 构】
：
Department of Radiation Oncology and Lineberger Comprehensive Cancer Center The University of North
【出 处】
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(BITs 3rd Annual World Cancer Congress-2010, Breast Cancer C
论文部分内容阅读
Growth and division are inherently disparate processes that are intimately coupled through a delicate network of intracellular signaling programs and extracellular stimulating events.A number of events imparting instability to ribosomal biogenesis can cause nucleolar stress and trigger activation of a p53-dependent checkpoint.A model for a ribosomal biogenesis-p53 checkpoint has been proposed based on the following circumstances: Nucleolar stress occurs following inhibition of ribosome biogenesis.Following nucleolar stress, several ribosomal proteins, including L5,L11, and L23, bind to Mdm2 and block Mdm2-mediated p53 ubiquitination and degradation, resulting p53 directed cell cycle arrest and apoptosis.The ribosomal protein-Mdm2-p53 pathway constitutes a surveillance network monitoring the integrity of ribosomal biogenesis.Latest progress using mouse models dissecting the signaling pathway will be presented.
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