Novel Insights into Regulation of Apoptosis in Uveal Melanoma: PERP-p53 Pathway

来源 :2014第七届世界癌症大会 | 被引量 : 0次 | 上传用户：zengguiyeah3

【摘要】

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【作者】

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Luminita Paraoan

【机构】

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Institute of Ageing and Chronic Disease Faculty of Health and Life Sciences University of Liverpool

【出处】

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2014第七届世界癌症大会

【发表日期】

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2014年12期

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　　Down-regulation of PERP (p53 apoptosis effector related to PMP-22) correlates with the aggressive (monosomy 3) type of uveal melanoma (UM), the most common primary intraocular tumour in adults.Signalling through the major tumour suppressor p53 pathway was reported as compromised in UM, but not due to defects upstream or at the level of p53, therefore pointing towards deregulation downstream of p53.

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Novel Insights into Regulation of Apoptosis in Uveal Melanoma: PERP-p53 Pathway

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