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Five new sesquiterpenes (1 5) along with ten known ones were isolated from the heartwood of Dalbergia odorifrea T.Chen.Their structures were determined by spectroscopic techniques including MS, UV, IR, 1D and 2D NMR.Bioassay results showed that compounds 1 and 9 had inhibitory effect on Candida albicans, and compound9 exhibited inhibitory effects on Staphylococcus aureus by paper disk diffusion method.