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Objective To investigate the clinical efficacy of simvastatin on acute coronary syndrome (ACS).Methods Al-together 120 patients with ACS were randomly divided into treatment group (n =60) and control group (n =60).Patients in treatment group received 20 mg simvastatin per night on the basis of conventional treatment.And patients in control group receivedconventional treatment only.Two months later the serum lipid levels and re-admission incidence were observed.Results In treat-ment group, the levels of triglyceride, cholesterol, low-density lipoprotein and high sensitive-C reactive protein decreased markedly and high-density lipoprotein increased significantly compared with which before treatment (P<0.05).There was no statistical difference on the levels of serum lipid post treatment in patients of conventional treatment.There was statistical difference on re-admission incidence for myocardial ischemia between treatment group and control group (P<0.05).Conclusion Simv-astatin is capable of regulating lipid and decreasing re-admission incidence in acute coronary syndrome.