Rational optimization of tumor epitopes using in silico analysis-assisted substitution of TCR contac

• 作 者: Shang Xiaoyun Wang Shufeng Wang Li Lin Zhihua Wu Yuzhang
• 机 构: InstituteofImmunologyPLA,ThirdMilitaryMedicalUniversity,Shapingba,Chongqing400038,PRChinaCollegeofCh
• 出 处: 全军免疫学第七届学术交流会暨免疫学新进展主题论坛
• 发表日期: 2009年9期
• 关键词: TCR Engineering HLA-A2 Molecuiar Modelling

　　Abbreviations:TCR,T cell receptor; MHC,major histocompatibility complex; CDRs:complementarity-determining regions; PDB,Brookhaven Protein Data Bank; EM,energy minimization; MD,molecular dynamics; SD,steepest descent;CG, conjugate gradient.ABSTRACT:αβT-cell receptors (TCRs)recognize peptide antigens presented by class Ⅰ or class Ⅱ major histocompatibility complex molecules (pMHC).Naturally selected TCRs are characterised by low binding affinities.