Cardiac Compartmental β2-Adrenergic Signaling Mediates Enhanced L-type Ca2+ Current but Unaltered Ry

来源 :The 10th Chinese Symposium on Calcium Signaling(第十届全国钙信号和细胞功 | 被引量 : 0次 | 上传用户：gotomis

【摘要】

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Aims: Distinct from β1-, β2-adrenergic receptors (β2ARs) mediate a compartmental cAMP signaling uncoupled from cytosolic proteins in heart, and regulate hear

【作者】

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Huaqian Yang Peng Zhou Shiqiang Wang

【机构】

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StateKeyLaboratoryofBiomembraneandMembraneBiotechnology,CollegeofLifeSciences,PekingUniversity,10087

【出处】

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The 10th Chinese Symposium on Calcium Signaling(第十届全国钙信号和细胞功

【发表日期】

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2014年7期

【关键词】

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excitation-contraction coupling ryanodine receptor L-type Ca2+channel β2-adrener

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Aims: Distinct from β1-, β2-adrenergic receptors (β2ARs) mediate a compartmental cAMP signaling uncoupled from cytosolic proteins in heart, and regulate heart function mainly by enhancing L-type Ca2+ channel (LCC) currents.LCC Ca2+ influx couples to ryanodine receptors (RyRs), which mediates SR Ca2+ release in Ca2+-induced Ca2+ release (CiCR) manner.However,whether β2AR-cAMP signaling modulates LCC-RyR coupling has not been determined.

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Cardiac Compartmental β2-Adrenergic Signaling Mediates Enhanced L-type Ca2+ Current but Unaltered Ry

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