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Mechanics prevails at all level of life processes.The emerging fields of mechanobiology focuses on how cells/organs/tissues generate, sense, transduces and respond to force.At the molecular level, how biomolecules adapt to the mechanical cues presents both technical and conceptual challenges.Intrinsically disordered proteins (IDP), existing as ensembles of malleable conformations, function in a wide range of catalysis, assembly and cellular signaling.