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目的：体外反搏在治疗许多缺血性疾病中有良好的效果，本文在重症失血性休克模型上探讨其保护机制。方法：采用一侧颈总动脉插管放血制造重症失血性休克模型，全程监测血压，实验结束时取左室心肌进行各项检查。结果：①反搏组反搏后血压显著高于反搏前，且实验结束时反搏组的血压也显著高于失血组。②失血组心肌内ＡＴＰ水平显著低于对照组及反搏组，而乳酸含量显著高于对照组及反搏组。③失血组心肌ＭＤＡ含量显著高于对照组及反搏组，而ＳＯＤ的活性则显著低于反搏组及对照组。结论：体外反搏可改善心肌的能量及自由基代谢
OBJECTIVE: Extracorporeal counterpulsation has a good effect in the treatment of many ischemic diseases. This paper explores its protective mechanism in severe hemorrhagic shock model. Methods: The model of severe hemorrhagic shock was established by cannulation of carotid artery on one side. Blood pressure was monitored throughout the procedure. Left ventricular myocardium was examined at the end of the experiment. Results: (1) The blood pressure of counterpulsation group was significantly higher than that of counterpulsation group, and the blood pressure of counterpulsation group was also significantly higher than that of blood loss group at the end of experiment. ② The level of myocardial ATP in the blood loss group was significantly lower than that in the control group and the EECP group, while the content of lactate in the blood loss group was significantly higher than that in the control group and the EECP group. ③ The MDA content in blood loss group was significantly higher than that in control group and EECP group, while the activity of SOD was significantly lower than that in EECP group and control group. Conclusion: EECP can improve myocardial energy and free radical metabolism