Impact of elevated serum glycated albumin levels on contrast-induced acute kidney injury in diabetic

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Background Glycated albumin (GA) has been shown to be a better indicator than glycosylated hemoglobin Alc (HbAlc) in terms of severity of renal impairment in patients with type 2 diabetes mellitus (T2DM).This study aimed to determine whether elevated serum GA levels are associated with an increased risk for contrast-induced acute kidney injury (CI-AKI) and worse clinical outcome in patients with T2DM and at least moderate renal insufficiency (RI) undergoing coronary Methods Serum levels of fasting blood glucose (FBG),HbAlc and GA were measured in 1030 patients with T2DM and moderate to severe RI (eGFR 15-59 ml/min/1.73 m(2)).CI-AKI was defined as ≥ 25% increase in serum creatinine within 72 h after the procedure.Receiver-operating characteristic curve was constructed to assess the predictive value of GA,HbAlc and FBG for CI-AKI.Multivariable logistic regression model was developed to identify risk factors for CI-AKI,and Kaplan-Meier curve analysis was used to compare the rates of dialysis and major adverse cardiac events (MACE) during one-year follow-up.
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