Two New Natural Products from the Fruits of Alpinia oxyphylla with Inhibitory Effects on Nitric Oxid

• 作 者: Li Yong hui Wang Yong Lai Wei yong Li Hai long Zhang Jun qing
• 机 构: SchoolofPharmacy,HainanMedicalUniversity,Haikou571199,P.R.China;HainanProvincialKeyLaboratoryofR&Don
• 出 处: 中国化学会第九届天然有机化学学术会议
• 发表日期: 2012年11期
• 关键词: Zingerberaceae Alpinia oxyphylla sesquiterpenoids structure elucidation anti-inf

　　Chemical investigation of the fruits of Alpinia oxyphylla led to the isolation of two new natural products,9-hydroxy epinootkatol (1),(S)-2-pentano1-2-O-β-D-glucopyranoside (2),in addition to nine known compounds,pinocembrin (3),tectochrysin (4),izalpinin(5),nookatone (6),yakuchinone A (7),protocatechuic acid (8),β-sitosterol (9),daucosterol (10) and β-sitosterol palmitate (11).Their structures were elucidated on basis of physicochemical constants and NMR spectral data analysis.The effects of the isolated components on nitric oxide production in LPS-induced RAW 264.7 macrophages were examined.The two new natural compounds showed inhibitory activities with IC50 values of 21.8 and 32.8 μg/mL,respectively.