Occurrence and Relevance of Maillard Products in Cancer

来源 :2013第六届世界癌症大会 | 被引量 : 0次 | 上传用户:new_spider
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Maillard products are formed by the reaction of sugars and amino groups during the baking and cooking of food causing its browning but also in the human body by intracellularly generated glycolysis intermediates yielding arginine-modified proteins and by oxidative stress yielding Nε-(carboxymethyl)lysine (CML) modification in proteins and DNA.This is of particular interest in relation to cancer cells since they exert high glycolysis rates (Warburg effect) and thus generate high intracellular concentrations of methylglyoxal, for example.Additionally, the detoxifying enzyme glyoxalase appears to be up-regulated in aggressive tumours.
其他文献
工程中的自动控制是应用控制器自动而有目的地操纵生产机械或过程,达到预定的工作状态。在自然界最复杂而又最神奇的控制器是人类的大脑和神经系统。于是越来越多的自动控制领域的研究人员投入到神经科学的研究中,期待利用控制理论及方法探索神经控制的机理,也希望从生物神经系统中学习高效智能的自动控制机制来服务工程控制系统的设计。本讲回顾控制理论在神经科学中的应用,并介绍本人相关的工作。
会议
The role of nutrients in dietary fibre (1) will be assessed to regulate cholesterol and amyloid beta (A) concentrations that are risk factors for Alzheimers disease (AD).The peripheral sink Ahypothesi
会议
In his classic 1981 (Learning and Motivation, 12, 239-260) work about spatial localization by the rat, Morris claimed that his results provided support for OKeefe and Nadels (1978, The hippocampus as
会议
NBM-T-L-BMX-OS01 (BMX) was derived from the semi-synthesis of osthole, isolated from Cnidium monnieri (L.) Cusson.The BMX was identified as a potent inhibitor of HDAC, and enhanced memory formation.Be
会议
Objective: Expression of monocarboxylate transporters-l(MCT1) of corpus callosum (CC) will be observed in different phase of neonatal rats.Methods: Different phases of neonatal rats were divided into
会议
Embryonic stem cells(ESCs)-derived oligodendrocyte progenitor cells(OPCs) transplantation can promote myelin regeneration, reduce secondary lesions and the risk of teratoma formation.However, the indu
会议
Patients with epilepsy are more prone to cognitive and behavioral deficits.Epilepsy per se may induce or exacerbate an underlying psychiatric disorder, a variety of factors contribute to such disorder
会议
The steady-state somatosensory evoked potentials resulted from external constant-frequency vibration stimulation is increasingly becoming a hot research in the field of brain-computer interface in rec
会议
Objective: To observe the therapeutic efficacy in using sulfotanshinone sodium and mecobalamin for treatment of patients with diabetic peripheral peripheral neuropathy.Method: A total of 114 patients
会议
The research adopted intragastric administration to give rats that were bound for five days Shu Yu naloxone and traditional Chinese medicine capsules, and found that ShuYu capsulecan significantly imp
会议