【摘 要】
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Maillard products are formed by the reaction of sugars and amino groups during the baking and cooking of food causing its browning but also in the human body by intracellularly generated glycolysis in
【机 构】
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Department of internal Medicinal, Section Clinical Chemistry, University of Tuebingen Germany
论文部分内容阅读
Maillard products are formed by the reaction of sugars and amino groups during the baking and cooking of food causing its browning but also in the human body by intracellularly generated glycolysis intermediates yielding arginine-modified proteins and by oxidative stress yielding Nε-(carboxymethyl)lysine (CML) modification in proteins and DNA.This is of particular interest in relation to cancer cells since they exert high glycolysis rates (Warburg effect) and thus generate high intracellular concentrations of methylglyoxal, for example.Additionally, the detoxifying enzyme glyoxalase appears to be up-regulated in aggressive tumours.
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