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BACKGROUND: Onyx has been widely adopted for the treatment of AVM.However, its control demands operator to accumulate a considerable learning curve.The authors present the initial experience by using a novel injection method for the embolization of AVMs.MATERIALS AND METHODS: The authors retrospectively reviewed the data of all 22 patients with brain AWs (12 men, 10 women; age range, 12-68 years; mean age, 43.2 years) treated by transarterial coil-augmented Onyx injection technique.The size of the AVMs ranged from 25 mmto 70mm (average 35.6mm).The technical feasibility of the procedure, procedure-related complications, angiographic results, and clinical outcome were evaluated.RESULTS: In every case, endovascular treatment (EVT) was completed.A total of 31 sessions were performed, with the mean injection volume of 6.1 mL (range, 1.5-16.0mL).An average of 96.7% (range 85%-100%) estimated size reduction was achieved, and 18 AVMs could be completely excluded by EVT alone.The results remained stable on follow-up angiograms.Procedural complication occurred in one patient, with permanent mild neurologic deficit.CONCLUSION: Their preliminary series demonstrated that coil-augmented Onyx injection technique is a valuable complement, which achieves excellent nidal penetration and improves safety of the procedure.