硫脲修饰聚天冬酰胺氨基乙烯衍生物的合成及其作为高效siRNA载体的性能研究

来源 :2015年全国高分子学术论文报告会 | 被引量 : 0次 | 上传用户：zhiming0077

【摘要】

：

小分子干扰RNA(siRNA)因其具有特定序列基因沉默的能力，有望用于治疗如癌症等多种疾病而受到极大的关注。然而由于siRNA 容易被酶快速降解，并且细胞摄取率较低，使得siRNA 的生物利用度很低，因此，迫切需要构建一种有效的转运载体。聚离子复合物(PICs)是最具发展潜力的转运载体之一。

【作者】

：

高辉陈祺先郭盼 Kazunori Kataoka

【机构】

：

天津理工大学化学化工学院,天津 300384 Department of Materials En

【出处】

：

2015年全国高分子学术论文报告会

【发表日期】

：

2015年7期

【关键词】

：

聚天冬酰胺氨基乙烯质子化作用基因沉默硫脲

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硫脲修饰聚天冬酰胺氨基乙烯衍生物的合成及其作为高效siRNA载体的性能研究

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