论文部分内容阅读
Pulmonary arterial hypertension (PAH) is a rare disease with a complex aetiology characterized by elevated pulmonary artery resistance, which leads to right heart ventricular aflerload and ultimately progressing to right ventricular failure and often death.In addition to other factors, metabolites of arachidonic acid cascade play an important role in the pulmonary vasculature, and disruption of signaling pathways of arachidonic acid plays a central role in the pathogenesis of PAH.We had reported that 15-LO-1 and 15-LO-2 are upregulated in PH patients and hypoxic anima PH model, which were localized in both PAECs and pulmonary smooth muscle cells (PASMCs);the synthesis of 15-HETE was increased in microsomes from hypoxic lungs and this effect is dependent on the lipoxygenase pathway.