Roles of Hinge Region,Loops 3 and 4 in the Activation of Escherichia coli Cyclic AMP Receptor Protei

• 作 者: ZhengyaGao;FengLi;GuangrongWu;YanrunZhu;TingYu;ShaoningYu;
• 机 构: Department of Chemistry, Fudan University, Shanghai 200433 China
• 出 处: 第七届全国化学生物学学术会议
• 发表日期: 2011年期

　　The cyclic AMP receptor protein (CRP) of Escherichia coli which is known to regulate the transcription of over 150 genes is a dimer made up of two identical subunits.Each CRP subunit contains a cyclic nucleotide binding pocket and a DNA binding motif.The protein, allosterically activated by cAMP binding, binds to DNA and interacts with RNA polymerase.