【摘 要】
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Objective To investigate the expression of Tyrosine kinase A (TrkA) in cerebral cortex neural stem cells of embryonic rats,the research tries to find functi
【机 构】
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Department of Molecular Biology, Medical Experiment Center, Shanxi Medical University, Taiyuan 03000
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
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Objective To investigate the expression of Tyrosine kinase A (TrkA) in cerebral cortex neural stem cells of embryonic rats,the research tries to find functions of TrkA and demonstrate the possible mechanism of neural stem cells directional differentiation during the development of neural system.Methods We take pregnant 13,15,17,19,21 d (E13,El5,El7,El9,E21) and postnatal 1 d (P1) Wistar rats to make paraffin section.We use Nestin to identify neural stem cells and then test the expression of Nestin and TrkA respectively and their coexpression using immunofluorescence (IF) double staining in above different stages.We calculate the average positive rate,demonstrated as ±SD and progress statistic analysis.Results TrkA distribute in rat brain tissue extensively during embryonic stage; the expression has following variance along with different developmental period:in cerebral cortices,at E 13 TrkA only express small amounts,step up at E15 then up to peak at E17,gradually decrease from El9 to E21 and increase a little at P1 in cerebral cortex.
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